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Baunthiyal, Mamta
- In Vitro Evaluation of Anti-Neprolithiatic Activity of Leaves and Seeds of Macrotyloma uniflorum on Dissolution or Removal of Kidney Stones
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Authors
Affiliations
1 G.B. Pant Engineering College, Pauri Garhwal, Uttarakhand, IN
1 G.B. Pant Engineering College, Pauri Garhwal, Uttarakhand, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 1 (2016), Pagination: 5-12Abstract
Nephrolithiasis is a chronic disease and in medical terms refers to formation of stones in kidneys. A renal calculus or kidney stone is a solid aggregation formed in kidneys from various minerals present in the diet. The kidney stones differ in sizes, shape and types. Kidney stone formation is a complex process that involves nucleation, supersaturation, growth, aggregation and retention within the kidney. The treatment of removal of kidney stones includes Extra corporeal Shock Wave Lithotripsy which can also sometimes cause renal injury. Various plant species have been used for the treatment of kidney stones. Macrotyloma uniflorum (Horse gram) is a popular pulse of Uttarakhand, locally known as Gaheth. M. uniflorum seeds are rich in protein, consumed in majority by poorest section of the society and are cultivated in India since prehistoric times. M. uniflorum seeds have been used by people of Uttarakhand for the treatment of kidney stones though till date no scientific explanation regarding its mechanism of action is known. The leaves have been used as a source of animal feed and are not consumed by humans. In the present study we focus on the comparative anti-nephrolithiatic activity of seeds and leaves of M. uniflorum and also the different bioactive components that may be responsible for dissolution of experimental kidney stones.Keywords
Anti-Nephrolithiatic, Calcium Oxalate, Kidney Stones, Macrotyloma uniflorum, Phytochemical Test, GC-MS Analysis.- Assessment of Intra-Specific Variation in Essential Oil Composition in Amomum subulatum Roxb. Cultivated in Uttarakhand, India
Abstract Views :425 |
PDF Views:162
Authors
Affiliations
1 Herbal Research and Development Institute, Mandal, Gopeshwar, Chamoli - 246401, Uttarakhand, IN
2 Department of Biotechnology, G. B. Pant Engineering College, Ghurdauri, Pauri Garhwal, IN
1 Herbal Research and Development Institute, Mandal, Gopeshwar, Chamoli - 246401, Uttarakhand, IN
2 Department of Biotechnology, G. B. Pant Engineering College, Ghurdauri, Pauri Garhwal, IN
Source
Asian Journal of Chemistry and Pharmaceutical Sciences, Vol 2, No 1 (2017), Pagination: 1-5Abstract
Large cardamom (Amomum subulatum) is native to Sikkim Himalaya and is important cash crop grown under the forest canopy. It thrives well between altitudes of 600 to 2000 m having an annual rainfall of 2500 to 5000 mm. Due to similar climatic condition and economic potential of the species, its cultivation was also started in Uttarakhand. Present study was design to analysis the chemical composition of essential oil and major compounds present in essential oil of capsule of A.subulatum grown in different agro-climatic region of Uttarakhand. The essential oil of 07 plant sample collected from different agro-climatic zones of Uttarakhand was analyzed through Gas Chromatography Mass Spectrometry (GCMS).The aroma analysis of chemicals present in essential oil was also carried out by two-fold, step wise dilution with dichloromethane. Oil yield was found between 2.5% to 3% for the sample of different agro-climatic regions. A total of 31 compounds were identified through Gas Chromatography Mass Spectrometry. 1-8 Cineol with 68% to 82.0% was the most dominant compound in all the samples. Other major compounds are 4-trimethyl (1.87% to 4.82%), β-pinene (1.88% to 3.56%), β-Terpineol (1.21% to 3.83%), Nerolidol (0.62% to 2.82%), DL limonene (1.01% to 2.51%) and Limonene (0.98% to 3.82%). Presence of higher concentration of essential oil (%) in all analyzed sample of Uttarakhand indicated that the species grown in Uttarakhand is may be of higher genotype. The GC-MS analysis of essential oil indicates quantitative variations within intra-specific and may attribute to the micro-climate under which the species grown.Keywords
1, 8 Cineole, Essential Oil, GC-MS, Genotype, Uttarakhand.References
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